Study on the effect of the ballistocardiography-based "Internet + Smart Bed" health management system on the quality of life of elderly users with chronic diseases.

Background: To study the effect of the "Internet + Smart Bed" health management system (IPBS) established with ballistocardiography (BCG) technology on the quality of life of elderly patients with chronic diseases. Methods: A total of 150 users with chronic diseases who had been staying in a nursing home during the period from January 2020 to March 2021 were enrolled and divided into 2 groups for experiments. The t-test and Bayesian methods were used to establish a generalized linear regression model to evaluate the effect of the IPBS on the quality of life of the subjects in the experiment. The control group (n=71) received routine examination and daily health risk management in pension facilities. Health service workers provided daily door-to-door care, and the users received regular diet, exercise, and medication supervision and guidance. The intervention group (n=79) was composed of users with chronic diseases, who accepted the IPBS. The health service workers, in addition to implementing routine examination and health risk management, conducted continuous monitoring and intervention management of the users' vital signs by means of the IPBS. Results: The results obtained with the Bayesian generalized linear regression model tended to agree with those of the t-test analysis. After 15 months of follow-up in the intervention group, the rates of body function, emotion, behavior compliance (BC), and health knowledge (HK) awareness were 1.47 times, 1.75 times, 1.53 times, and 1.69 times higher than those in the control group, respectively. In the intervention group, after using the IPBS, all scores of quality of life were better than those before use, and the differences were statistically significant P=0 or P=0.1 (P<0.05). In the control group, there were no statistically significant differences before and after observation (P>0.05). Conclusions: Routine management in elderly users with chronic diseases by means of the IPBS, which could change the users' bad living habits and eating habits, raise the patients' HK awareness, and comprehensively improve the quality of life of patients with chronic diseases, is a self-health management model worthy of application and promotion.

Generation of a Human iPSC (ICSSUi002-A) with MTHFR SNP (rs1801133, TT) from Thoracic Aortic Dissection Patient.

Thoracic aortic dissection is a devastating cardiovascular disease with an increasing annual incidence. The homozygous mutation in rs1801133 site has been accepted for decreased enzyme activity of mutant MTHFR protein, contributing to an accumulated homocysteine in blood. Recently, elevated homocysteine level is causally associated with an increased risk of cardiovascular disease. Conversely, the relationship between rs1801133 and thoracic aortic dissection is poorly understood. Here, the generated human induced pluripotent stem cell (iPSC) line provided a novel strategy for investigating the underlying mechanism of MTHFR mutation (rs1801133, TT) and its implication in the pathogenesis of thoracic aortic dissection.

Generation of Marfan patient specific iPSCs (ICSSUi001-A) carrying a novel heterozygous mutation in FBN1 gene.

Marfan syndrome (MFS) is an autosomal genetic disorder caused by mutation in FBN1 gene, encoding the extracellular matrix protein fibrillin-1. Here, a MFS patient specific iPSC carrying a novel heterozygous mutation (c.7897 T > G) in FBN1 gene was generated. This iPSC line exhibited normal morphology and karyotype, and could differentiate into three germ layers in vivo and in vitro. Thus, the established iPSC line provided a precise platform for elucidating the molecular pathogenesis and personalized drug screening of MFS.